Hey Matt, it all kind of depends on how the amp is used. If you’re frequently using the amp (4-?) times a week on a regular basis, it’s usually a good idea to change them once every year/year and a half for the amp to preform and sound as optimal. However tubes can last a lot longer than that. I’ve had the tubes in my Marshall head for about 4 years at this point and while it probably doesn’t sound as great as it can potentially, it still preforms pretty well. Rule of thumb though is about once a year. Hope that helps!